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KMID : 0389420100180030209
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Korean Journal of Stress Research
2010 Volume.18 No. 3 p.209 ~ p.217
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Effects of Gambisu Inhalation on the Expressions of Neurotransmitters Implicated in the Food Intake in the Hypothalamus and Cognition of Starved Mice
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Kim Dong-Hyun
Ko II-Gyu
Kim Sung-Eun
Kim Ji-Eun
Kang Yeon-Ho
Kim Tae-Woon
Ji Eun-Sang
Kim Yong-Min
Kim Ee-Hwa
Kim Jeong-Beum
Kim Dong-Hee
Kim Chang-Ju
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Abstract
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In the present study, we investigated the effects of Gambisu inhalation on the expressions of neurotransmitters implicated in the food intake in the hypothalamus and cognition using starved mice. For this, the effects of Gambisu inhalation on the expressions of leptin and neuropeptide Y (NPY) in the paraventricular nucleus (PVN) of hypothalamus of starved mice were evaluated by immunohistochemistry. Short-term memory of the mice was also assessed using a passive avoidance task and brain-derived neurothrophic factor (BDNF) expression in the hippocampus was determined by Western blot analysis. ICR mice were divided into three groups: control group, starvation group, and starvation with Gambisu inhalation group. The mice in the food-deprivation group were restricted food for 48 h. The mice in the Gambisu inhalation group were exposed to inhale Gambisu for 60 min twice a day for 2 consecutive days. The present results showed that food-deprivation decreased leptin expression and increased NPY expression in the PVN of the hypothalamus. Food-deprivation decreased short-term memory ability and also suppressed BDNF expression in the hippocampus. However, Gambisu inhalation increased leptin expression and decreased NPY expression in the PVN of hypothalamus under the starvation conditions. Gambisu inhalation alleviated starvation-induced short-term memory impairment and enhanced BDNF expression in the hippocampus under the starvation conditions. The present study revealed that Gambisu inhalation might suppress desire for food intake and exert beneficial effect on cognition by enhancing BDNF expression in the hippocampus under the starvation conditions.
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KEYWORD
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Gambisu inhalation, Starvation, Leptin, Neuropeptide Y, Short-term memory
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